The CNDR operates as a centrally-coordinated network of major neuromuscular clinics located across Canada. Each centre operates through a local Principal Investigator (typically a practicing neurologist with a research interest in one or more neuromuscular disorders) under local ethics approval. Each centre is guided by the national CNDR ethics 'umbrella'.

Regional centres are structured to encompass all practicing physicians and affected patients within a particular geographic area. Collaborative participation is welcome.

The CNDR Advisory Committee, consisting of scientists and disease experts, oversees the clinical datasets and reviews requests for research access to the registry.